2.
A large volume of distribution (Vd) means that:
Possible Answers
a. There is a high concentration of the drug in the plasma.
b. The drug is likely to be highly bound to plasma proteins.
c. Less total drug is outside the blood in body tissues.
d. Drug that is displaced from plasma proteins will move out of plasma into
tissues.
Ryants
Favorite Answer
D. Vd is basically the volume in the body that the drug goes. So making up some random numbers, lets say Drug A could only stay in the blood, a volume of about 5L. And Drug B could diffuse out of the blood and into the brain/CSF as well, which is about 150ml. So Drug A would be in 5L of volume and Drug B would be in 5L + 150ml. Drug B would therefore have a higher volume of distribution. Hope that helps!
My 2 Cents
YA isn't about posting your entire set of homework questions to get the answers. It's about finding help when you are truly stuck on something or need further clarification.
I wouldn't want you as my health care practitioner (pharmacist, physician, nurse ... whatever school you are in) if you aren't even going to take the initiative to do your own homework.
Try doing your own homework. I guarantee you'll learn and retain more information that way.