cardiac contractility question?
do you know the mechanism of decreased contractility due to barbiturates?
do you know the mechanism of decreased contractility due to barbiturates?
JBi
Favorite Answer
Barbiturate mechanism of action:
http://en.wikipedia.org/wiki/Barbituate#Mechanism_of_action
Barbiturates act on the GABAa receptors to prolong the action of GABA. GABA is the principal inhibitory neurotransmitter in the CNS. So it's inhibiting or decreasing all sorts of actions in the brain including cardiac function and respiration. Increasing GABA also decreases the release of glutamate which is an excitatory neurotransmitter in the CNS. This leads to further inhibition of CNS mediated function including cardiac and pulmonary function. So basically, barbiturates make the CNS send fewer signals to the heart resulting in decreased contractility.
gangadharan nair
Common causes of cardiomyopathy are:
* Alcoholism and cocaine use
Due to decreased contractibility, the end systolic volume will be higher and the ejection fraction will be less.
The outlook depends on many different things, including:
* Severity of the heart problem
* Type of cardiomyopathy
* Cause of the cardiomyopathy
* How well you respond to treatment
The disorder is long-term (chronic) and the condition may get worse very quickly.