husoski
The easy way to find a directional derivative is to take the dot product of the gradient with a unit vector in the desired direction.
Your unit direction vector is û = <cos 5π/4, sin 5π/4> = <-1/√2, -1/√2>.
The gradient of z(x,y) is:
∇z = <∂z/∂x , ∂z/∂y>
...with:
∂z/∂x = e^(2x - 3y) + (x) (2) e^(2x - 3y) = (1 + 2x) e^(2x - 3y)
∂z/∂y = (-3x) e^(2x - 3y)
∇z = <1 + 2x, -3x> e^(2x - 3y) [after factoring out that common exponential]
So the direction derivative in the direction of û is
D_û z(x,y) = ∇z • û = [-(1 + 2x)/√2 - (-3x)/√2] e^(2x - 3y)
= (-1 - 5x) e^(2x - 3y) / √2
At the point (x,y) = (1,-2), that's 9 e^8 / √2.