Describe how the stability is generally for 5 rings and 6 rings and what factors affects the energy level (stability) of such rings.?
During the development of new antiviral drugs, natural products are often used as a starting point. Such a thing
antiviral diterpen is shown in structure 7.
Describe how the stability is generally for 5 rings and 6 rings and what factors
affects the energy level (stability) of such rings. (8 p)
During a further development of antiviral drugs, one can start from
structural elements in natural products. The choice here is based on cyclohexane
1,2-diol.
f) Draw cyclohexane-1,2-diol (8) on cis and trans form in its most stable conformations
and indicate which is most stable. Justify the answer. (8p)
One of the stereoisomers of cyclohexane-1,2-diol does not rotate plane-polarized light. Describe
which and why. What class does this connection belong to? (5 p)
h) Synthesis of alcohols can be done via several different ways. One way is hydration
alkenes using strong acid and water as shown in the reaction scheme below. Vis
the reaction mechanism for the formation of 10 from 9. (10 p)
i) Describe why the substituents end up in the positions they do during the hydrogenation (5 p)