Does any body know what Zollinger-Ellisin Syndrome is?

ZES is a rare disorder characterized by one or more tumors in the pancreas, duodenum, or both. The tumors cause the stomach to make too much acid, leading to peptic ulcers in the duodenum. The tumors are sometimes cancerous and spread to other areas of the body.

ZES is caused by tumors called gastrinomas, which release the hormone gastrin.

Normally, cells in the stomach produce and control gastrin so only the right amount is released. Gastrin travels through the bloodstream to signal other cells in the stomach to release gastric acid to help break down food. Gastrinomas release abnormal amounts of gastrin, resulting in excess gastric acid in the stomach and duodenum. The excess acid eventually causes sores called peptic ulcers to form in the lining of the duodenum.

Scientists are unsure what causes the majority of gastrinomas, which appear sporadically. About 25 percent of gastrinoma cases are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1).1 MEN1 can cause a variety of hormone-releasing tumors such as prolactinomas and insulinomas. Prolactinomas form in the pituitary gland in the brain and cause excess prolactin—a hormone that influences milk production, fertility, and bone strength. Insulinomas form in the pancreas and cause excess insulin—a hormone that helps control blood glucose, also called blood sugar. Signs and symptoms of MEN1 include increased hormone levels in the blood, kidney stones, diabetes, muscle weakness, and weakened bones and fractures.

Anyone can get ZES, but the disease is more common among men 30 to 50 years old. People with MEN1 have a 20 to 61 percent chance of developing ZES.2 Children who have a parent with MEN1 have a 50 percent chance of inheriting the MEN1 gene and are, therefore, also at increased risk of ZES.

ZES symptoms are similar to those of peptic ulcers and include

burning abdominal pain

nausea and vomiting

weight loss

diarrhea

severe gastroesophageal reflux—a condition where gastric acid and food from the stomach backs up into the esophagus.

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Is a disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often the cause is a tumor (gastrinoma) of the duodenum or pancreas producing the hormone gastrin. Gastrin then causes an excessive production of acid which can lead to peptic ulcers in almost 95% of patients