Did any of the GOP candidates do well into their 40 and fifties and then lose it all and have to start over?

While some of them started out poor, that's not the same as losing your job in your fifties along with your home and health insurance and having to start all over. Have any of them faced an expensive illness for a family member without health insurance? A lot of people are facing that today, but none of the folks up on that stage seemed knowledgeable or even sympathetic to this reality. Should they have given a statement about their feelings about that and what help, if any, should be extended by 'government' at what ever level would be appropriate?