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Will a Grignard reagent add to the carbonyl carbon of a carboxylic acid? Why or why not?
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- Anonymous9 years agoFavorite Answer
Carboxylic acids have an acidic hydrogen, and a Grignard reagent is a base, so an acid-base reaction will occur, making the GR (a nucleophile) into a "non-nucleophile." So it won't work.
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