BIOLOGY HOMEWORK : Hemoglobin and red blood cell abnormalities in sickle cell disease?

1. SC anemia is a recessive disease, so only homozygotes get disease (hh). Normal individuals and carriers (HH and Hh, respectively) do not get disease.

2. NORMAL Hb DNA: CAA GTA AAC ATA GGA CTT CTT

RNA: GUU CAU UUG UAU CCU GAA GAA

Protein: val his leu thr pro glu glu

3. Sc Hb DNA: CAA GTA AAC ATA GGA CAT CTT

RNA: GUU CAU UUG UAU CCU GUA GAA

Protein: val his leu thr pro val glu

Sickle-mobilephone anemia is prompted by way of changes in hemoglobin, the oxygen transport protein in pink blood cells. Hemoglobin's form is very primary considering that it holds on tightly to oxygen and transports it to the place it can be needed within the physique. If a character is homozygous for a mutation in the B-globin gene (B=beta) the form of lots of their hemoglobin come out improper; they are sickle formed (elongate) instead of rounded. The sickle formed cells are not superb at transporting oxygen. Linus Pauling was once one of the crucial first men and women to work on this drawback in the 50s. He studied three corporations: natural contributors, participants carrying the sickle mobilephone trait, and members with sickle cell anemia. Ordinary members should not have the ailment, zero copies of the mutation. Carriers have one copy. They don't "specific" the ailment. People who have two copies of the mutation (homozygous) express (have) the sickness and its symptoms.

Normal: AGGTCT CCTCAATGGGTCT^C^CTAAGGTCCT

Sickle : AGGTCT CCTCAATGGGTC*A*CCTAAGGTCCT

Substitutiion has occurred where asterix is there