Is drinking wine and smoking a cigarette a sin?

It is important to find the just measure for each thing; to consume in the just measure never does bad .

Harming your body is a sin, so yes.  Smoking is a sin.  So is drunkenness.  Drinking alcohol in moderation is not.

I believe so. our body belongs to the lord.

"Do not ye yet understand, that whatsoever entereth in at the mouth goeth into the belly, and is cast out into the draught?" (Matthew 15:17)!

Drinking alcohol is not a sin, and smoking cigarettes is not a sin.  Drunkenness is the sin, and like all sins, it is forgiven completely when the person believes in the Lord Jesus Christ.  Death leads to heaven or hell.  The Lord Jesus Christ is God, who died on the cross and shed His blood to pay for all of our sins in full, and then Jesus was buried, and then Jesus resurrected from the dead.  Nothing you could do will ever pay for any of your sins.  Jesus already paid for all of our sins with His death on the cross and His shed blood, and then Jesus resurrected from the dead.  So the only way to get into heaven and avoid hell, is by believing in the Lord Jesus Christ, without adding any of your own works.  See Romans 4:5.  It is too late for you to be saved, after death.

Why would it be. Jesus turned water into wine. Smoking anything is not listed as a sin or anything like that. Incense plays big in the Bible. That's not smoking but you do ingest the smoke if you are close enough. 

 Maybe to someone who is religious . But in my opinion as an atheist very certainly not........

What did they drink at the last supper....?

(And theres another yarn about Jesus supposedly turning water into wine also.)