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Mr E

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  • **Advance topic** GPCR Hyperactivation?

    So I'm working with a receptor that is a GPCR. I am screening receptor agonists using a calcium mobilization assay. What I found was that my agonists hyperactivate the receptor in a dose-dependent manner up to 250%. My question is if this is unheard of, or if it is common, and what causes hyperactivation? I ruled out washing as the reason for the increased activation

    2 AnswersBiology1 decade ago