Who is the most famous person that ruined his or her career the most by something they said?

I do believe Michael Richards is the winner on this one, although he really didn't have much of a career anymore since Seinfeld was cancelled....but I think Isaiah Washington is a close second....

Michael Richards, Tim Hardaway

Michael Richards, Whoopi Goldberg, Mel Gibson, and Dixie Chicks.

I'm surprised no one thought of this but back when Sinead O' Connor was popular if you ever saw her speech at the MTV awards that def ruined her career not to mention the whole pope picture burning thing.

Mel Gibson also.

I don't know if this ruined her career but Marilyn Monroes whole happy birthday mr. president thing must have done some damage.

And your definently right about john rocker. I haven't heard from him since. He did that in the glory days of the braves and height of his career.

Michael Richards or Kramer....from Seinfeld

John Rocker he was amazing till the braves traded him because of waht he said.

Sinead O'Connor saying, "fight the real enemy!" as she tore up a photo of Pope John Paul II on Saturday Night Live.

michael richards, mel gibson (remains to be seen if it does permamnent damage) bill clinton (i did not have sexual relations with that woman it got him impeached, almost),

Brittany Spears, when she said YES to Keven Federline!!!!!!

michael richards.tom cruise.