What can I say?

My best friend of nearly 6 years is gettng married on February second. I'm her Maid of Honor, my second time being one (although the first didn't mean half as much to me as this one). The last time, the bride wanted a very untraditional wedding and there were no speeches, no toast, no tossing of anything.

This time, however, I'm supposed to give a speech at a reception that looks to be about 100 people.

Now, there's a twist. She's marrying my fiance's brother, whom I've also known for about 6 years (they beat us to it, lol). I love them and their 3 month old daughter, my neice, very much and I have a few ideas on what to say, but I'd like to hear a few other opinions, too.