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Need help with opening programs and IE...Virus?

Im trying to open programs and IE on my computer. It keeps asking me to "open with" in a pop up. Im assuming its a virus. If it is virus how do I even run my AVG or Malwarebytes to get rid of it? I have tried safe mode and it doesn't work. All my programs i try opening are saying program no found.

Any help with instructions would be great thanks.

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