What bike do you suggest 6'6" 350lbs?

With your height and weight a BEE Emm would still be easy for you to handle assuming you already know how to ride.

Try out the 650 for a possible starter bike then look at the G S's as a 2nd bike a year or so later.

Been BE EM ing for 40 years had most models but went GS 30 years ago and ride all year round snow and all, it's a long learning curve but hang in there, Enjoy. Good Luck.

I would begin with engine size for a start and I think commuting if that will be the main purpose.

You are a big man so you are going to have to factor in how that is disposed on your frame whether it is from a weight problem or a health body size. You have to manage the strength to pick it up onto it's wheels if you go over.

There is also the profile of the layout of your city whether it is all flat terrain or a lot of hills as you want something with enough grunt to get up the hills and not put puting up the hill in second gear.

I am out of touch with bikes but there are some great ones available since I last had one.

Most fellas your size ride full dress Harleys.