TV series actors with bad luck in their career?

In a discussion in another forum, some acquaintances and I made note of the fact that actress Andrea Anders has had an unfortunate track record: she keeps getting cast as a principal character in sitcoms that get cancelled within two seasons ("Joey," "The Class," "Better off Ted," "Mr. Sunshine"), the TV equivalent of box office poison. Her "Mr. Sunshine" co-star Matthew Perry had a similar problem before "Friends" came along, and since "Friends" seems to be back to the old pattern of failed comebacks. I guess Joanna Garcia almost qualifies, but "Reba" had a healthy seven-year run.

Are there any other actors you guys know of who seem to always show up as leads in new series, only to have those series axed prematurely?