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how "dangerous" is it to double-dose medication?

I've been taking more than the Recommended Dosage on cold & flu meds as long as I can remember, when I NEED to because I'm sick...and never thought anything of it because nothing's ever come of it, nothing bad anyway, I usually take my "double-dose" once or twice a day and back to feeling fine the next day. That is, until, my buddy went to Pharmacy Tech school (and has become the universe's leading expert on medication after completing a 6-month school).... gave me the 3rd and 4th degree because "they put the dosage on the bottle to keep you safe" blah blah blah... yeah, I get that if I take 32 tylenol at once it'll probly be my last headache but in REALITY, how likely is it to have an adverse reaction to taking a double-dose of Theraflu or Nyquil or whatever other cold remedies there are??

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  • A T
    Lv 4
    8 years ago
    Favorite Answer

    You're operating on the assumption that more is better --- it isn't. With all medications, there's a zone known as the "therapeutic index" -- in essence, it's the range of doses where the benefits of the medication outweigh the risks. Below this range, you don't get benefit, but you're unlikely to experience bad side effects. Above this range, the risk of serious toxicity increases, while you don't get much increase (if any) in how effective the medication will be. Most nonprescription medications have a pretty wide therapeutic index, meaning that as long as you follow the instructions on the bottle, the doses will be safe for the vast majority of the public. However, when you increase the doses on your own, you can run significant risk of toxicity, especially with products containing acetaminophen. While you sarcastically ridicule your friend's 6 months of training, I'd point out that this is six month of formal training you haven't had..... Your friend is absolutely correct in that you should not be doubling the doses on your own -- you're not really getting extra benefit, but you are getting extra risk....

    Source(s): PharmD
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