Manually removing a computer program that won't allow it?

I have an HP laptop bought in 2008, with Vista. I have been cleaning it up so there's less 'garbage' on it. Over the years, I have downloaded 2 programs that I cannot uninstall from the control panel. Stop Sign by e-acceleration, and Device Manager (don't recall the publisher). In Control Panel, I can see a list of every program. These two won't uninstall. I get a window that asks to proceed (allow or not allow) and it tries to do one of two things: allow- runs the program, and closes the window, but, won't uninstall. Don't allow- just closes the window. I have tried countless times to uninstall them. What do I have to do to circumvent the built in features that prevents the uninstall and get them eliminated once and for all?