Rabbit's nails?

Okay so my rabbit lives in my bedroom with me and has free range of the room. He's always been extremely stubborn and doesn't like to be held. I don't really mind because that's just how he is; however, I have no idea what to do about his nails. He doesn't even like to be touched half of the time, let alone let me touch his feet. But his nails are getting so long and I can tell when he's hopping around that his nails bother him. And you're supposed to keep them trimmed anyways. I know exactly how to do it as I trim my dogs and Guinea pigs. However, my rabbit is sooooo stubborn. I tried wrapping him in a blanket to calm him down, I tried doing it while he was sleeping, I even tried having someone else trim while he relaxed as I pet him. I just don't know. So this is probably a dumb question but I was wondering if you could give a rabbit medicine to calm them for a minute whilst trimming?? If so what kind and how much?? Thank you.