Multiple choice - When retinoblastoma protein is inactivated, how is cell division affected?

Question

a - Genes that are required for passing the G1-S checkpoint are transcribed, translated, and the cell passes from G1 to S.
b - There is no effect on the cell cycle, although cells may experience a change in transcription of certain genes.
c - There is continued inhibition of transcription of genes required for passing the G1-S checkpoint; therefore, the cell arrests in G1.

Jaz Han · Accepted Answer

Answer: Genes that are required for passing the G1-S checkpoint are transcribed, translated, and the cell passes from G1 to S.

Function of retinoblastoma protein:
it is a  tumor suppressor protein.
its function is to prevent G1-S progression of cells with damaged DNA inducing G1-S arrest.
thus acts as a G1-S checkpoint control.

Inactivation of rb protein will allow the cell to progress to S phase even with damaged DNA. The end result is uncontrolled division of a DNA damaged or mutated cell leading to cancer.

Multiple choice - When retinoblastoma protein is inactivated, how is cell division affected?

Related Questions

Trending Questions