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Multiple choice - When retinoblastoma protein is inactivated, how is cell division affected?
a - Genes that are required for passing the G1-S checkpoint are transcribed, translated, and the cell passes from G1 to S.
b - There is no effect on the cell cycle, although cells may experience a change in transcription of certain genes.
c - There is continued inhibition of transcription of genes required for passing the G1-S checkpoint; therefore, the cell arrests in G1.
1 Answer
- 8 years agoFavorite Answer
Answer: Genes that are required for passing the G1-S checkpoint are transcribed, translated, and the cell passes from G1 to S.
Function of retinoblastoma protein:
it is a tumor suppressor protein.
its function is to prevent G1-S progression of cells with damaged DNA inducing G1-S arrest.
thus acts as a G1-S checkpoint control.
Inactivation of rb protein will allow the cell to progress to S phase even with damaged DNA. The end result is uncontrolled division of a DNA damaged or mutated cell leading to cancer.
