What causes an old scar to randomly puff out and itch?

I have an old scar on my arm from a picc line, 4 yrs old now. I've woken up a few times over the years with it puffed out and super itchy, but it usually goes away within an hour.  What would cause this? No other scars on my body do that. 

2017-04-11T00:37:33.809Z