Best on screen chemistry??

adam sandler - drew barrymore

wedding singer and 50 first dates were awesome.

John Travolta and Uma Thurman-Pulp Fiction

Jimmy Stewart and Grace Kelly -Rear Window

John Wayne and Maureen O'Hara- The Quiet Man, McClintock!, The Wings of Eagles

Meg Ryan and Tom Hanks-Sleepless in Seattle, You've Got Mail, Joe vs. The Volcano

Meg Ryan and Kevin Kline- French Kiss

Humphrey Bogart and Katherine Hepburn- The African Queen

Bogie and Bacall -everything they did together

Spencer Tracy and Katherine Hepburn- Guess Who's Coming to Dinner?, Desk Set, Adam's Rib

Julia Roberts and Hugh Grant- Notting Hill

Renee Zellweger and Colin Firth-Bridget Jones's Diary

Nicholas Cage and Holly Hunter-Raising Arizona

Val Kilmer and Robert Downey Jr.-Kiss Kiss Bang Bang (didn't love each other, but worked very well together)

Robert Redford and Paul Newman- Butch Cassidy and the Sundance Kid, The Sting

I think it has to be a tie between Richard Gere & Julia Roberts, (Pretty Woman and Runaway Bride) and Keanu Reevees & Sandra Bullock, (Speed and The Lake House). The on screen chimisry between these talented and gifted actors/acctresses is so electric that the audience feels it and can't help but react to it. You leave knowing you gotten more than your money's worth.

Humphrey Bogart & Lauren Bacall, in several movies. Its very obvious they had the major hots for each other.

Best male chemistry is Jack Lemmon & Walter Matthau in "The Odd Couple"..just brilliant double act.

Frodo and Samweis, you just can't beat that chemistry (just kidding)

I dig Natalie Portman and Clive Owen in the strip club scene in The Closer, as well as Natalie Portman and Zack Braff in Garden State.

John Travolta and Nicolas Cage - Face Off

George Clooney and Jennifer Lopez in "Out of Sight", Dennis Quaid and Ellen Barkin in "The Big Easy", and of course, Michael Douglas and Kathleen Turner in both "Romancing the Stone" and "War of the Roses"

reese witherspoon and ryan phillippee. cruel intentions. i always think it's neat to see how real life couples interact in movies. especially when they have to be mean to each other. you could tell ryan was getting really upset. i also think the two people that starred in the notebook had amazing chemistry.

Humphrey Bogart and Lauren Bacall in "Dark Passage"

Katherine Hepburn / Spencer Tracey

All their films

John Wayne and Maureen O'Hara - McClintock and The Quiet Man are two...can't recall if they were in others together.