Best Hotel to stay at for 2 nights in San Francisco?

For your visit Union Square is probably the best place to stay. There are lots of good restaurants, shops, theaters and clubs in the Union Square area. It is centrally located easy to walk to many places, easier to get cabs, with lots of public transportation options. Driving in the city can be confusing for visitors and parking is difficult and expensive. Muni offers multi day passes that are good for buses, trolley, light rail and the cable cars [unique experience but $5 per ride].

http://www.sfmuni.com/

Joie de Vivre http://www.jdvhospitality.com/ has several hotels in the Union Square area within your budget. Each hotel is unique and they have a cool free program where they match you with a local person, called a Golden Gate Greeter, who shares your interests to spend a few hours with you and familiarize yourself with the city. http://www.goldengategreeter.c.../

And for some great ideas of things to do check out these websites:

http://www.jdvhospitality.com/thingstodo...

http://www.mistersf.com/

aha! ooo i'm from san francisco!!!! the marriot would be good. theres also an embassy suites hotel...id say both have great views...union square is quite a spot but id stay away from chinatown..go into the wrong part of it and you might get jumped [chinese gangs]

the serano is VERY NICE. it is a boutique. it is on o'farrel. i suggest to book it online, my family got it very cheaply. very nice hotel, i was VERY pleased!