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4 Answers
- oputzLv 41 decade agoFavorite Answer
Yes, angiotensin II (AII) is a polypeptide. It results from the conversion of angiotensin I through the activity of angiotensin I-converting enzyme (ACE). In fact, ACE is a dipeptidase with at least ten identified substrate such as bradykinin, substance P, GnRH etc. ACE cleaves the Phe-His bond of AI, hus setting free the C-terminal His-Leu, resulting in the active form, AII (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). AII is a vasoconstrictor and serves numerous functions, among them blood pressure regulation, organogenesis, male fertility, ovulation and others.
Source(s): Classic studies on angiotensin include Skeggs, Kahn, and Shumway, J. Exp. Med. 103 (1956): 295-299 and Erdös and Sloan, Biochem. Pharmacol. 11 (1962): 585-592. But you'd be better off with a recent review article. Particularly, one that focuses on the physiological role of AII as well as its phylogenetic distribution. AII is really a rather universal enzyme found both in vertebrates and invertebrates. Here a few recent ones: Cohen JD, 2007, "Overview of physiology, vascular biology, and mechanisms of hypertension," J Manag Care Pharm. 13(5):6-8. Callera G, Tostes R, Savoia C, Muscara MN, Touyz RM. 2007. "Vasoactive peptides in cardiovascular (patho)physiology." Expert Rev Cardiovasc Ther. 5(3):531-52. Dimitropoulou C, Chatterjee A, McCloud L, Yetik-Anacak G, Catravas JD. 2006. "Angiotensin, bradykinin and the endothelium." Handb Exp Pharmacol. (176 Pt 1):255-94. Re RN. 2004. "Tissue renin angiotensin systems." Med Clin North Am. 88(1):19-38. Takeuchi K. 2002. "Molecular biology of blood pressure regulatory genes." Tohoku J Exp Med. 197(1):1-8. Inagami T, Kambayashi Y, Ichiki T, Tsuzuki S, Eguchi S, Yamakawa T. 1999. "Angiotensin receptors: molecular biology and signalling." Clin Exp Pharmacol Physiol. 26(7):544-9. Inagami T. 1999. "Molecular biology and signaling of angiotensin receptors: an overview." J Am Soc Nephrol. 10 Suppl 11:S2-7. - Anonymous1 decade ago
its a plasma protein.. lol i see ur taking physiology too.. good luck ur going to need it
