Can you help me out with this?

My wife has a chronic illness (Secondary Addison's Disease) and must take 12 - 15 medications per day. Essentially, her endocrine system is not functioning and she has to replace virtually everything the endocrine system would otherwise provide to her body. A couple of those medications have caused her to gain about 40 extra pounds...and the doctors say that she's probably going to keep gaining. She is very depressed about that (she takes medication for depression, too. It's helping.) She keeps running herself into the ground saying, "I'm a big fat pig!"

I feel completely useless in that I can't say or do anything to make her feel better about herself. She has always had a great body and never had to worry about her weight. Now, she has no control over it whatsoever. She just keeps gaining. I tell her that I love her, I help around the house as much as I can, tell her she's still beautiful, etc., but nothing seems to help. What can I do or say to boost her morale?