What is a great vacation spot for memorial day weekend?

Well since you state Blast, Girls time, Great, and that I suspect you're not inclined to NYC, it won't yet be beach weather/temps, and not strictly knowing your ages or interests, you may not enjoy many Touristy areas, in New England, that are more subtle perhaps.

Some of this notion you have also depends on budget, and how LONG this weekend will last. It makes little sense to me to Fly to Vegas for an overnight.

If I were in your position, I'd probably get it kind of settled, before that weekend, and plan, or reserve NOW, then in your choices, also research the various locations, narrow them down to time and affordablility, and activities certainly.

Just my opinion, and it may now sound so touristy to you, but a girls weekend in NYC, could be as exciting as anywhere else on the planet.

Certainly if you had major $$$ You could see the Sunrise in Bermuda, make in time for a great lunch in Chicago, catch the Sunset in San Fran., do a late morning brunch in Hawaii, the next day, Catch a movie on a plane, East again to Cancun, for a VERY late night beach party, and be back in NYC in time for late night snacks and Cocktails at the Hilton in Manhattan, probably in a 3 day weekend.

cape cod, washington dc, vermont so you don't have to travel far and the prices are low..or take a weekend getaway to vegas or florida-good prices for getaways during that time.

Cancun is super. bypass to an all-inclusive lodge and that they had have Corona and margaritas on faucet poolside. you need to drink all you like and not might desire to difficulty approximately that important liquor bill on the final of the holiday!