Pimafix and Melafix says do water change after 7 days wont these lead to a massive build up of medicine??

Melafix is a homeopathic remedy rather than other chemical medicines. It's melaleuca (tea tree oil) and hasn't proven to have any effect on a tank's biological filtration. I've never had any problems dosing it in tanks per the label's instructions. I believe it's 5 ml per 10 gallons not 10 litres (10 gallons = 37.8 litres). The only complaint I have for this product is that it can produce plenty of surface bubbles/foam when present in the aquarium. I've had good results using the product but I've heard plenty of others say it didn't do anything for them.

Melafix and Primafix are basically additives to help reduce the risk of disease and help heal torn fins etc.

If you tank is heavily overstocked or a tiny tank (betta less that 1 gallon) then you will need to monitor your ammonia, nitrite and nitrate levels. If any of them start to climb to a dangerous level then you will need to do a water change. Under normally stocked aquariums 1 week without a water change is the general schedule everyone follows so should not be a problem.

Hope this helps

Melafix and Pimafix are not medications-- it is essentially giving your fish a bath in tea. Regardless of your water change schedule, the chances of it healing the fish is slim. If you have faith in the "medication", just follow the instructions on the bottle-- as long as you have a filter, you shouldn't have any issues (if you don't have a filter, that is likely why your fish is sick to begin with).

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Melafix and Primafix have worked great for me in the past.

What size tank do you have?

Filtration?

Stocking?

Why are you treating your fish?

Pimafix and melafix aren't legitimate medicines anyway. They're tea tree oil and at best will irritate your fish to the point where it produces more slime coat.

I'd ditch that and get something that works.

well, im pretty sur they can't OD on the stuff if that's what you're asking....

what are you trying to treat? soop's right in that they are basically herbal and bark extracts form various plants...

the water changes every week will also do good, just in the fact that you are doing them is going to help your fish.