I'm replacing my motherboard, but keeping my HD, and I use Vista Home Premium. Will there be a problem?

You really need to just re-install. Here is why. When you change your Mobo and CPU you have to think of all the hardware changes you are making. Such as audio and video drivers, Ethernet drivers, USB and firewire. All those and some. Your current system is loaded with the drivers it needs for your current board. If you change that out you run the risk of an unstable system. So save yourself the headache and just backup stuff and re-install. However in my opinion you should just roll back to XP, but thats just me.

Yes if there's a major hardware change (like mobo) then WinXP or Vista will need to re-authorize. It should be automatic but if you're required to call, just tell 'em the old motherboard died and you replaced it.

Be sure to boot from your operating system CD and do a repair install first- otherwise your system might crash badly at startup (the old motherboard chipset drivers are incorrect for your new system)

u got the vista dvd u install it no need to contact microsoft as i know ... u got the original vista dvd u are the one whose going to install it ok ... i suggest u back up every file u need out of the hard disc and completely reinstall vista after u change ur mb and the processor cuz i also did change my mb and the processor from my older once to newer once and i had vista i plugged everything and vista started fine but it was really slow as i know i had to format and reinstall cuz hardware changes such as the procssor or the mb are doing really big differences to ur operating system so install ur mb and processor and reinstall vista ... or else if u dont never except to run ur machine in its real performance that match ur new hardware ... this is the same even for the rams ...

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yes, unless you uninstall all the drivers from your old motherboard off your hard drive then you are gonna end up in the blue screen of death

The OS should be OK since you are keeping it intact on the HDD

you will have to do a repair as it will not run. Vista is like XP if you change things it doesn't like it.