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help with infected with SpyRid and Trojan.Popwin?

ok i just scaned my pc and this is what it says,, how do it get ride of them.. I have MCafee but somehow they got past it what do i do now

C:\Documents and Settings\user\Local Settings\Temp\.ttE.tmp is infected with SpyRid

C:\Documents and Settings\user\Local Settings\Temp\ae7b771hpb771a.exe~ is infected with Trojan.Popwin

Update:

i have windows xp

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