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How does angiotensin converting enzyme (ACE) know to interact with angiotensin I instead of angiotensinogen?
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- 1 decade agoFavorite Answer
angiotensinogen is 452 amino acids long. after renin is activated it cleaves the Luecine and Valine bond in the first 12 amino acids. this leaves you with a 10 amino acid peptide. which then ACE interacts with angiotensin 1 one by removing the HIS and Leu amino acids at the end of the ten-amino acid peptide. It cannot interact with angiotensinogen because i'm guessing its too big.
Source(s): you can read more about it here. http://en.wikipedia.org/wiki/Angiotensin
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