Does more weight and more speed equals more energy?

Yes, kinetic energy = (1/2)mv^2. So it increases with mass and with speed.

I don't have the data to be able to calculate the power output. The reason you would need power to sustain a constant speed is to overcome friction, which for a ground vehicle means air friction and rolling friction with the tires. So you need some assumptions about size, number of tires, cross section area, etc and some reference data for typical coefficients of friction.

At that speed and mass, the chances of surviving a collision with a car are zero. A tractor trailer is much less massive than that, and in a collision with a tractor trailer at normal highway speeds, automobile passengers don't have much chance.

I had an encounter with a smallish truck that didn't see me and switched into a lane that I was already in. I was flicked off the road like a bug. I'm fortunate that it was more of a glancing blow. It sent me into a horizontal spin into the guardrail, but after spinning around 4 or 5 times we came to a halt, still upright, and relatively uninjured.

Weight is not significant. Mass is. Energy is dependent upon mass and velocity.