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How does Olanzapine work (Question for pharmacists, or other healthcare profesionals)?
I understand that Olanzapine is an antagonist at both dopamine D2 and 5-HT2 receptors (among others). Now, I can see why Olanzapine may reduce the positive symptoms of schizophrenia and related disorders as it acts to block dopamine at the receptor site, but I can't work out why introducing a 5-HT2 antagonist (as olanzapine is) would reduce the negative symptoms. Surely this would decrease serotonin transmission in the brain and increase the negative.
I note that aripiprazole is a 5-HT2 agonist and I can understand why it would reduce negative symptoms.
If someone could please explain Olanzapines mode of action, I'd be most grateful.
Yes, I too have been on Olanzapine, albeit a low dose (for anxiety/paranoia from traumatic event). In relation to my mood, I don't believe it helped or hindered, though it did help with the paranoia. training to be a psychiatric nurse right now, hence why I'm asking the question.
1 Answer
- HDLv 71 decade agoFavorite Answer
I am not a doctor or pharmacist but I was on zyprexa for years and it certainly does increase negative symptoms. I think it is perhaps the worst 2nd generation anti psychotic there is. I took an SSRI with it to help with serotonin but it didn't really help much.Do you have any of the literature that comes with the medication?
