Does anyone have experience with Vaginitis in dogs?

You're right, these usually are self-limiting and they'll 'grow out of it'.

I'm afraid I have more questions than answers...but maybe one of the questions will trigger something...

Top on my list of things to consider: Are you *sure* you're clearing it completely? Or do you think its a reinfection? Or is it normal flora getting out of hand? How's the urine (both between and during an episode)? Are there any other systemic signs you can go after?

My textbook has the following to say about vaginitis:

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...A non specific vaginitis is fairly common in puppies prior to their first estrus and usually clears up after the estrus cycle is completed...Cultures taken through a sterile vaginal speculum may indicate the causative bacteria. Interpretation of culture results may be difficult because the normal vaginal flora can potential pathogens. In general gram negative organisms are most often associated with infections.

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In terms of a holistic approach --- what are you feeding? I assume from your post that its a high quality food, but which one? Have you tried a different diet? What is her skin/coat like? Stool quality? (what I'm getting at, is the possiblity that this could be related to something outside the urogenital system) I don't know if probiotics often have an impact on the vaginal microflora, but I wonder if there is a similar approach?

Is it possible that the antibiotic treatment might be perpetuating the problem? (this may be totally off the wall). If the antibiotics aren't particularly selective for the pathogen, you might be altering the microflora? (Knock out everything --- including the good, and the bad might grow back as likely as the good?)

Again, a lot of speculation above --- I wouldn't take anything *too* seriously, but consider it, and maybe chat with your vet about the possibilities.