Can a former U.S.president run again once he is out of office?

Yes, and it has happened, that is why grover cleveland was #22 and #24... however, since the 22nd Amendment, you can only be president 2 times...many think that means consecutive, it does not...

Section 1.

No person shall be elected to the office of the President more than twice, and no person who has held the office of President, or acted as President, for more than two years of a term to which some other person was elected President shall be elected to the office of President more than once. But this Article shall not apply to any person holding the office of President when this Article was proposed by Congress, and shall not prevent any person who may be holding the office of President, or acting as President, during the term within which this Article becomes operative from holding the office of President or acting as President during the remainder of such term.

Section 2.

This article shall be inoperative unless it shall have been ratified as an amendment to the Constitution by the legislatures of three-fourths of the several States within seven years from the date of its submission to the States by the Congress.

At present, only 2 living presidents could run again... carter and GHW Bush.

If he has only served 1 of 2 terms then yes. If he's been in office for 8 years (2 terms) then no.

yes as long as he hasnt served 2 terms or 6 years in office

Yes, as long as he (or she) was not impeached. President George W. Bush was the last president in office for two terms. President Grover was the only president to be in the office for two non-consecutive terms.

If he only served one term.No one can be president for more then two terms.

Not if he or she had 2 terms. Not unless the 22nd amendment is repealed or deemed unconstitutional.

The answer is yes, if he hasn't served two consecutive terms.