Can you help me find out what this Germ based movie was called?

I remember this movie from a while ago. The germs talked and one of the main characters was a blue germ. I remember him wearing a brown/black jacket. The germs lived in this man's body. When they showed the germs, the germs appeared to be cartoonish, but when they showed the man the man was actually a real person. This movie also inspired a cartoon series but I forgot what it was called as well.