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meaning of knockout in this sentence?
Hi, I need some help with the meaning of 'knockout' in this sentence:
"The interpretation of body-weight results obtained from Pcg-1-α knockout-mice is inherently difficult"
The text mentions, above, mice who were deprived from PGC-1-α, so could it mean mice that don't have PGC-1-α?
Thank you!!
1 Answer
- Anonymous8 years agoFavorite Answer
It's not the "knockout", it's "knockout-mouse"
A knockout mouse is a genetically engineered mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
Source(s): Wikipedia, baby.