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Cancer is a disease of the cells?
It occurs when there is a failure of cell cycle control. What types of changes could occur to cause a cell to become cancerous? What genes would be affected and why? Why would a cell cycle checkpoint need to be nonfunctional in order for cancer to develop?
2 Answers
- 8 years agoFavorite Answer
Changes to a cell's DNA cause mutations and hence, possibly cancer. This could be because of carcinogens (chemicals such as nicotine) or exposure to high frequency radiation. Once this cell's DNA is mutated, the coding instructs it to undergo extremely rapid mitosis- much faster than an ordinary functioning cell- hence a "tumor" forms. When this becomes malignant, the cells travel into neighbouring tissue and when it reaches the blood vessel, it is very difficult to get rid of.
- 8 years ago
The lack of cyclins from a DNA mutation would cause the change. I would assume the affected genes would be the ones that are replicated into mRNA that end up producing the cyclins. If the cell cycle was functioning then the cells would not grow out of control.
Source(s): Bio.