Is it possible to be friends with neighbors at this point?

Okay, so to make a long story short, I have been having a hard time with my neighbors for over three years now. My next door neighbor seems friendly, and talks to many of the neighbors and has get-togethers sometimes. After being neighbors and being on friendly terms for around 8 months, I was hanging out with them and with another couple down the street. The first neighbors didn't talk to us directly and made us feel like we were given the cold shoulder. I then realized that they hadn't ever invited us over or spoken to us like friends. They seemed to undermine us with the other couple. Also, I've never spoken to the wife for more than a few words at most. I became alienated with the other couple(who has since moved anyway). Another neighbor who is friends with my neighbor stopped talking to us much. His wife used to bake us things, but when I went over with a cake, her father puled up and asked her whether she was okay. I felt very offended, as if I were being regarded as a stalker and that she and her husband weren't close enough to us that her father even knew we were friendly neighbors. Our relationship fragmented into virtual alienation after that. Fast forward, another neighbor moved in and we accidentally imposed on them when we were trying to be friendly and not let this happen again. The woman is now openly disrespectful to my wife and daughter and we now hate them. So, at this point, I don't want to be antisocial, but I'm stuck! What should I do?