Should I quit my job that makes my life miserable?

I am in the same boat as you. My job have a high turnover and they don't high people fast enough to replace the ones that quit. I have been in this job for 15 months and I feel exactly what you feel, which is sucking the life out of me. I literally got off the plane this week at 6 am and went straight to work after going to another province for my master's degree. Unlike you I have mortgage and master degree tuition on my own. I do have parents that can help me a bit but I should bare with the pain. I will never quit a job without an offer, as mentioned above, it looks better if you are employed then unemployed when going to interviews. Just bare with it while looking elsewhere like I am doing now.

If you don't like your job, then you should get another job. It'll be much easier to get another job while you still have your current job.

If your bills are low, then you might switch to part time, rather than full time. But I don't know if it makes sense to stop working altogether.

If you can't handle the stress of a management position, then maybe you should switch to a lower level position.

Any two, or all three, of those suggestions can be done at once.

"retail... is very demanding physically"

No. It is not.

If you want to stay home and can afford to do so, that's your decision. If you want a new job, I'd start looking before you quit. Don't forget, it's not just the salary you lose - it's also the benefits.

Unless you can find a better career, you can't afford to quit because you will be putting more pressure on your spouse. There are times in life we have to make sacrafices

If it's gotten to the point where you have to choose between your job and your health, then absolutely choose your health. But before you jump, I'd put a little thought into what you'd rather be doing beyond simply getting out of there, and what you can do to position yourself to make that jump before you resign.

A big employment gap won't help in getting your next job, would you be willing to go to school for a year to start you in a new career.?

yes quit