if the insignificant human race were annihilated would...?

Unlikely another species would fill the shoes and become anything like humans. Only three species on the planet have civilisations and that's Humans, Ants and Termites.

Any new race would take millions of years to evolve, and wouldn't understand politics

Politics form from having an organized society, not really pointless. While some people are good, many have bad agendas and complete chaos would exist.

doubtful

Yes. IN A BILLION YEARS, LIKE IN DOCTOR WHO. GET YA TARDIS READY AND WOOOOOOOO WRRR WOOO

You're so wise. NOT!

the human race is not insignificant