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- 2 decades agoFavorite Answer
IF it is an actual cyst, you need to have it looked at. The location could raise cause for concern. But there are a number of other possibilities that you should rule out first. The most obvious I would suggest would be a simple callous. DO you do something where excess skin might be needed in your palms, if so, don't worry about it. You can shave it down or apply some keracin lotion and over time it will go away. If it is a cyst, you need to have it checked out by your Dr.