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Paracetamol overdose ?
This question is primarily aimed at mental health professionals, doctors, paediatric nurses and so on, able to give fairly expansive answers. Please refrain from unhelpful remarks like "she'd be dead, innit"
If 25g (50 tablets) of paracetamol were ingested by a 14 yr old female, who was then successfully treated approx 18hrs post ingestion, what would be the anticipated long term effects and would they include and increased risk of heart attack?
Please bear in mind that I am not a 14yr old female looking to OD!
Also to pharmacists or anyone who has an informed opinion on the subject!
By successful I mean not dead or suffering immediate liver or kidney failure etc.
In this scenario I posit that there was some alcohol, cannabis and ecstasy misuse prior to OD (not immediately prior) and alcohol and cannabis misuse after discharge
I forgot to thank everyone who has answered so far! It is really appreciated.
Also, what kind of term are the possible effects of the OD that are mentioned here - immediate and posing a risk for the next 6 months, after 12 months and indefinite etc?
6 Answers
- 1 decade agoFavorite Answer
This could depend on an number of factors including the definition of 'successful treatment'. I'm not sure what that would entail as the paracetamol would've been processed by the liver by that time, & it's the liver which can be damaged by paracetamol OD.
It would also depend on the state/efficiency of the liver before the OD as a previously damaged liver is obviously more at risk.
Long-term, this type of OD can cause damage to the liver - some repairable some not. Liver Function Tests (LFTs) would tell you more. Having a damaged liver will require examination of the diet, meds, etc.
In terms of heart attack I've not encountered this as a long term effect of Para OD.
Many of those I've worked with have fully recovered (physically) from para ODs of similar proportions, however most of those were been adults with previous substance/alcohol misuse problems. Young people are not fully developed so may be more at risk. Previous substance misuse also increases risk (generally)
Good luck, hope all goes well.
Source(s): Mental Health Professional - substance misuse, adults & young people. - tanika971Lv 71 decade ago
Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.
- 1 decade ago
About 30 tablets can cause poisoning. But if she was treated successfully than i think she will have not serious adverse effects. But there are no proper studies regarding heart attack risks in future, so it is difficult to tell this definitively.
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- lady bLv 41 decade ago
your question should have been directed to a pharmacist; in any case, pcm's main toxic effect due to overdose is hepatotoxicity, i.e. it destroys or packs the liver cells, which will end the blood production for the whole body.
- Anonymous1 decade ago
A pretty long answer but you may want to read it
About 3 weeks ago, I temporarily lost my mind due to various things. I took an overdose consisting of 50 paracetamols, 10 codamols and 5 neurofen. There's one thing i learnt from this which is you can't die til its your time to die.
I took the OD on a thursday at around 1am. I told my bf and he turned up outside my house and tried forcefully taking me to the hospital because i was to scared to face my parents. I refused and went back home saying I would call 999 myself. I then warned him saying i wouldn't n if he did i would take more pills. This was the worst night of my life. Constant vomiting, Headaches and my head felt numb. My stomach was burning and I jus felt like i was dying. I fell asleep arounf 6am and was woken by my mum at 9. I told my mum what u had done but i didnt tell her how many i took.
THE BIT YOU NEED TO KNOW...
At 8pm my dad had enough of me lying in bed and crying although he didn't know what i had done. He rushed me to a&e where i was given a blood test and while i was waiting for the results thinking i could go home, All the doctors were looking at me like i needed to be in a padded room somewhere or handcuffed like a criminal or just a plain nut job. My results came after i had 4 blood tests. The worst being in my wrist where they take blood from your artery for a kidney test. The pains unbearable as they fish inside ur wrist to find it. They then immediately put me on a drip and told my parents that they should immediately get my close family to the hospital to see me because they weren't sure i would survive to see the next day. I had all my family surrounding me in the ward crying and looking at me as though they were saying good bye. I was throwing up blood at this point and still in so much pain. I began to txt my close friends last words and constantly had doctors around me asking me why i did it. did i know it would kill me. did i try to kill myself and would i do it again. I felt so stupid and humiliated. My family left at 2am and the doctors let my bf and best friend in. She just cried at left. My bf told me that if anything happened to me he would kill himself as my dad did earlier and these were grown men crying around me. The guilt took me over. I've never seen him in so much pain. I was scared to sleep that night incase i didnt wake up and i just kept txting him the things i wanted him to do after i was gone. Eventually i fell asleep for an hour and was woken again by a nurse doing another blood test.
I survived the night and the drip i was on managed to clear soem toxins but still the levels were to high. My liver was barely working and the enzyme drip was doing the job for it. The days went by. My arm was numb from the drip. I was then discharged the following friday. I spent 9 days there and thats worse then what i was going through before the OD. It was hell constantly attached to the drip machine. As the doctors told me again and again I was very very lucky to survive and its a rare occurance that this happened becuase of the amount and the time lapsed til i went a&e.
All i can say to you is that my lifes changed for the better now. Its only been 2 weeks since i've been out. Im so happy to be alive but my severe headaches haven't stopped. the dizzyness hasn't stopped. I still have the numb feeling in my head and sleep for 12 hours a day because i'm so tired. Also the looks from my family and the questions being asked havent stopped. I feel stupid. I've had 2 pyschiatrists phone my house now and all i can think is i'm not crazy. Why did i put myself through all that and there were other things i could have done but not an OD. Trust me there are other ways. Not only that, I'm 20. Your alot younger than me and im sure my liver will be more tolerable than yours because i drink regularly and my liver clears that up everytime and i've been drinking for 6 years. I wouldn't chance it.
If its not your time to go you won't. You'll be put through pain and misery. It's not worth it.
I wish you luck in whatever you decide to do. Try learn from my mistakes and don't do it. Talk to someone about whats bothering you.