two different hp printers, one computer, two hard drives?

It should work just fine. I've had a scanner, two inkjets, an all-in-one laser scanner, and a 54' wide format printer all hooked to one pc. One was parallel with a usb converter.

The only thing is if you have a small power supply you may want to get a usb hub with it's own power source.

The number of drives does not matter, other than taking more power.

The drivers for each device will install into the Operating Systems driver directory on one of the drives.

Absolutely possible. I've got two printers and two disks on my own system, plus USB thumb drive ability AND camera SD chip ability as well. No conflicts whatsoever.

XP, no problem, just remember which alphabet designation is which device.

Vista, well, my Home Premium box gets confused between my Sprint Mobile Broadband USB, and a single flash drive! I have to power down Sprint and remove it, before juggling files I/O the flash drive!

Hear that Microsoft?!?

Disconnect the standard Serial Bus (USB) cable from the returned of the product, yet bypass away the product became on Open the conceal of the product and eliminate the print cartridges close the conceal and look ahead to the Insert Ink Cartridges message to reveal Disconnect the potential twine from the returned of the product and look ahead to one minute Reboot the computing gadget Reconnect the potential twine. If the product does not immediately activate, press the potential button Open the conceal and reinsert the print cartridges close the conceal. If introduced on, print a calibration internet site. Reconnect the USB cable, and attempt to print a print activity from the computing gadget