when using paxil , what part of the day is best to take them?

They can make you drowsy so a few hours before bed is probably best, don't plan on chasing any women while you are taking the stuff.

I take generic Wellbutrin SR (150 mg) in the morning, and Lexapro (10 mg) with dinner, for depression and anxiety. I've been taking that for over two years, and it's working very well for me.

The Wellbutrin SR seems to help me to be more alert and active - and wanting to do things - while the Lexapro makes me more mellow, and it helps me sleep better, too. They are relatively low doses of each medication, which keeps side effects at a minimum. I really can't tell I'm taking any medication at all.

There are a lot of people that take Wellbutrin with their SSRI's and SNRI's, it helps to counteract some of the possible side effects - such as drowsiness, weight gain, and the sexual side effects. It really does make a difference!!

I would suggest taking the Paxil about 5 hours before bedtime. I found (by experimenting) that the best time for me to take my Lexapro is with dinner. I sleep better at night, and I'm more awake the next day.