Mucus membrane absorbtion?

I basically know most of what i need to know about all drugs in general, but at a time in my life I didnt. When i was much younger, me and my friends would basically steal any abusable presciption pills from our houses or wherever we could find them, and blow every oe regardless. Back then, trust me many many pills were snorted. Even vicodin, as pathetic and nasty as it is. Any benzo, any painkiller, ambien, wellbutrin, adderall, ketamine, ritalin, muscle relaxants, coke, one time i even remember blowing neurontin, and zoloft and paxil for ***** sake. SSRI's? Now that is sad (no pun intended). I knew nothing at that point about administration bioavailability, i do now though. As an early warning to anyone about to tell me how dumb I am/was for doing any of this, shut the **** up and get back to your cubicle.

After this period of my life, 31 on my ACT testing (chopped as **** during it too), got a web designing job at the age of 16, highschool teachers basically telling my parents that im some sort of a child genius. Sounds irrelevant, but im just adding that so no one jumps to conclusions or get some pre-conceived notion that all of that damaged my brain. I have no superiority complex fyi.

My real question is if any of the prior medications wih all those nasty binders and chemicals could have damaged my mucus membrane to the point of lowering the bioavailability of insufflation? What gave me the idea was one night where I blew 80 mg of oxycontin (which has an amazing bioavailability with insufflation since its pure oxycodon), then the next day i just popped an 80 (parachuted of course) and felt it way more. Many other experiences similar to this with different pharms.