In the case of the soul, why is it difficult to conceive that the immaterial could affect the material?

But some kind of immaterial entity called 'information' doesn't affect us, as far as we can tell it's all physical.

Your physical brain does physical processes, gives neural commands to your throat muscles, which cause sound-waves, which are picked by physical receptors in the other person's senses, which is then physically transmitted to the brain, which physically processes it.

And the stumbling block in believing in a soul isn't that we can't imagine it, it's that there's no reason to believe it actually exists. In fact there are strong arguments against its existence which I could list here.

Edit: The organization on a floppy disk is very much material. I really don't see how you could argue otherwise. The information resides in the structure of the disk and the reader that reads it, that the organization is material doesn't mean we should expect extra matter to have been added into there when the information resides in the way the physical structure is organized. None of this supports the idea that the immaterial can affect the material.

I agree that any number of concepts which have no physical form have real world effects but I would submit to you the possibility that it is merely our belief of a soul which has any effect not the actual existence of the thing. Just as with things like democracy or 'the system' it requires a belief in the immaterial to have any effect and thus in relation to this argument I put forth that the soul is attached to the human condition of religion and thus if you are going to discard the belief in God for logical reasons then you can just as easily discard the belief in a soul because they are often linked theologically.

That would suggest the soul is information. Most people who believe in the soul think of it as of a substance which is essentially the same kind of substance as physical matter rather than having a more abstract nature.

And I submit to you, that my family, surroundings and certain situations * material * has molded me. This would be the material producing the immaterial

There is no 'soul' that you 'have'. This is all a part of a complex control plot. You don't HAVE a soul you ARE a soul.

You have no evidence for it. Everything that has no evidence is impossible to believe.