please give me some advice.?

I live in a very small town, rural NC. jobs are scarce. my last 3 jobs have ended in being laid off although i have 15 yrs. experience i can't get the regional hospital dept. manager talk to me, even when she posts a job that is 'right up my alley' i have never met her, don't know her from adam...or anybody else for that matter. when i call or leave a msg, apply on line or visit the dept personally and ask her to call me ...she doesnt. she had the person i spoke with call me back and say she didn't need anybody! how unprofessional. i have visited the HR dept. directly to apply for the last job posting saying i couldn't reach her and they said 'she's the person i need to talk too" now there is a new posting for a position i am well suited for. what should i do????