Will Pluto ever smash into Neptune?

Pluto orbits on a different plane than the rest of the planets. The locations where the orbit of Pluto appears to intersect Neptune's orbit (areas circled in red below) do not actually intersect at all.

You can think of their orbits like two connected links of a chain. They cross over each other but do not occupy the same space along any point.

If natural resources (plutonium) are extracted from the planet at a rate that significantly affects the planets orbit, it could have the opposite affect. Given the weight of Plutonium metal, this would cause what ever planet that is harboring the plutonium (most likely greedy earth, Europe, complaining about ozone all the time) to begin to become smaller by the pyroplasmic implosion that is the Pt reacting. And, Pluto will increase in size. This will offset orbits, but will not cause a collision. The magnetic forces of adjustment will first affect Saturn. It has included within its mass debris that will be most affected by the change in magnetic fields. This debris field will most likely collide with earth (greedy Europe for taking too much Pt, in the first place >laugh this is humor<). In order for this senerio to become a true one so much mass would have to be removed from Pluto, that the space ship wouldn't be able to return. And remember that Pt becomes more dense with the acceptation of protein. This senerio isn't probable.

No. Even though their orbits look like they're overlapping in a flat plot, in reality Pluto's orbit is tilted by 17 degrees to that of Neptune, so the two never come close to each other.

For the forseeable future no. There is no intersection .

Chaos theory proves that orbits are unstable in the long term, but the Sun will be a Red Giant and our species will be long gone before there is the faintest possibility of any of the planets changing orbit significantly.

No, extremely unlikely (not impossible but the odds are very very low)

No, they're orbits are stable.

No.... their orbits never intersect.