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What would happen to chromosomes in absence of kinetochore microtubules during metaphase?
Would they simply be suspended at random? It is unclear to me whether the pull mechanism of the microtubules is that which aligns them along the equatorial plane.
1 Answer
- 6 years ago
The mitosis will be suspended, the overall cell cycle will be delayed, to give chance to repair process to solve the problems. If the repair is success then the cell cycle will be resumed.
Since kinetochore microtubules (kMT) are important element, needed for the complete separation of sister chromatids or homologous chromosomes, the absence of kMT can lead to generation of aneuploidy. In the normal, generations of aneuploidy can be avoided by targeting the abnormal cells towards apoptosis.
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