After pipe leak under the house, there is a large bubble in the floor above. It is about 2 feet in diameter. Should I move the refrigerator?

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Move the fridge and put a piece of plywood where the floor is bad and move the fridge back .  That will keep things in place till you can get the floor fixed permanently . 

About the refrigerator:  The floor is giving out huge cracking noises in that area, like wood breaking, at night.  The refrigerator is on the side of the mobile home that has settled over time.  The bubble is more toward the middle of the house.  I think as the bubble is raised, that is where one of the steel beams is located.  I am concerned that the refrigerator weight on the side of the mobile home could cause the floor and side of the house to buckle.  It would ruin the refrigerator as well as the floor.  I was told it would have to be fixed, but have nowhere to go while the house is open to the cold winter weather.

No.  The weight of the refrigerator is what keeps everything stuck together.  Just throw a rug down in front of the frig and forget about it.

Er...why would you move the refrigerator?